翻訳と辞書 Words near each other ・ Lost and Found (disambiguation) ・ Lost and Found (Feeder song) ・ Lost and Found (IU EP) ・ Lost and Found (mixtape) ・ Lost and Found (Mudvayne album) ・ Loss given default ・ Loss leader ・ Loss mitigation ・ Loss network ・ Loss of chance in English law ・ Loss of China ・ Loss of citizenship ・ Loss of consortium ・ Loss of control ・ Loss of heterogeneity ・ Loss of heterozygosity ・ Loss of Innocence ・ Loss of right in English law ・ Loss of rights due to conviction for criminal offense ・ Loss of Sensation ・ Loss of Signal ・ Loss of significance ・ Loss of Strength Gradient ・ Loss of supply ・ Loss of tail-rotor effectiveness ・ Loss of the Kink Salient ・ Loss of United Kingdom child benefit data (2007) ・ Loss of use ・ Loss of Words ・ Loss on ignition Dictionary Lists mini英和辞書 mini和英辞書 Webster 1913 Latin-English FOLDOC Wikipedia English ウィキペディア

翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Loss of heterozygosity ： ウィキペディア英語版 Loss of heterozygosity Loss of heterozygosity (LOH) is a gross chromosomal event that results in loss of the entire gene and the surrounding chromosomal region.〔(of the autoimmune diseases scleroderma with an immunologic response to cancer, ) Christine G. Joseph et al., Science, 343:152 (10 January 2014)〕 Most diploid cells, for example human somatic cells, contain two copies of the genome, one from each parent (chromosome pair); each copy contains approximately 3 billion bases (Adenine (A), Guanine (G), Cytosine (C) or Thymine (T)). For the majority of positions in the genome the base present is consistent between individuals, however a small percentage may contain different bases (usually one of two for instance ‘A’ or ‘G’) and these positions are called ‘single nucleotide polymorphisms’ or ‘SNPs’. When the genomic copies derived from each parent have different bases for these polymorphic regions (SNPs) the region is said to be heterozygous. Most of the chromosomes within somatic cells of individuals are paired, allowing for SNP locations to be potentially heterozygous. However, one parental copy of a region can sometimes be lost, which results in the region having just one copy. The single copy cannot be heterozygous at SNP locations and therefore the region shows loss of heterozygosity (LOH). Loss of heterozygosity due to loss of one parental copy in a region is also called hemizygosity in that region. ==In cancer== The loss of heterozygosity is a common occurrence in cancer, where it indicates the absence of a functional tumor suppressor gene in the lost region. However, many people remain healthy with such a loss, because there still is one functional gene left on the other chromosome of the chromosome pair. However, the remaining copy of the tumor suppressor gene can be inactivated by a point mutation, leaving no tumor suppressor gene to protect the body. Loss of heterozygosity does not imply a reversal to the homozygous state. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Loss of heterozygosity」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.